VOC sampling locations table for Ground Zero area, Jan 2002

NYC 9/11 Public Portal Document

Table 16. Experiment B: BAL Supernatant Biochemical Values after macrophages and lymphocytes is probably a Nose-Only Exposure “ nonspecific reaction to inhalation of large Group Day Protein Albumin LDH NAG amounts of dust which induces macrophage Ug/ml Ug/ml U/L U/L recruitment for phagocytosis and clearance of Air 1 165.2 21.0 29.0 1.5 the particles (Adamson and Bowden, 1981). 3.4 0.1 Levels of proteins and enzymes in the BAL — 147.1 I 16.9 supernatant were assessed in the two groups of WTC3 1 23.9 1.6 6.7 I 1.2 3.3 0.1 mice at 3 time points (Table 16). Significant differences between Air and WTC3 groups were Air 3 136.6 16.2 33.0 1.8 found for total protein (P = 0.05) and albumin (P 10.4 1.2 6.4 0.0 = 0.007), but there was no significant day effect. WTC3 3 138.1 I 15.8 28.9 1.6 Surprisingly, the levels of protein and albumin 7.8 I 1.5 3.4 0.1 were higher in the Air group. However, the Air 6 172.6 22.4 30.2 1.4 overall levels of all proteins and enzymes was 2.4 0.2 low in both groups and at all time points (Figure WTC3 6 146.5 I 17.5 27.1 1.4 14), in comparison with Experiment A. The 6.8 I 1.1 3.1 0.1 results indicate that at this exposure ° Values shown are means (in bold) and SEM immediately below means (n=8 per concentration and duration, WTC3 PMj j does group). Heavy solid-line boxes: Significant overall treatment effect (WTC3 < Air; not induce severe acute lung injury. no significant day effect); P = 0.05 (Protein) or P= 0.007 (Albumin). 7. Nasal histopathology. No exposure- related nasal lesions were found in mice exposed neutrophils and eosinophils were about 0.1% or less of to air alone (controls). Similarly no nasal lesions were total BAL cells, indicating that WTC3 did not induce a found in the mice exposed to WTC3 and killed 3 or 6 days significant acute inflammatory reaction. The increase in post-exposure. None of the mice in any group had

Protein LDH 250 □ Air 75 l«WTC3 □ Air C 200 a ■■WTC3 B eJ 50 5 150 S as I 100 3.

ijl k. A. 50

0 0 Day 1 Day 3 Day 6 Day 1 Day 3 Day 6

Albumin NAG 50t 10 □ Air □ Air ■■IWTC3 8 B HIWTC3 eiD a .5 25- ■ a I aa 6

B Q 4 J 5! ■ 2

0- 0 Day 1 Day 3 Day 6 Day 1 Day 3 Day 6 Figure 14. Experiment B: BAL supernatant biochemical values in mice 1, 3, or 6 days after 5 hr nose-only inhalation exposure to WTC3 or Air only. Values shown are means and SEM (n=8 per group). “ Significant overall treatment effect (WTC3 < Air; no significant day effect); P = 0.05 (Protein) otP= 0.007 (Albumin).

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NYC-WTC_000149173