VOC sampling locations table for Ground Zero area, Jan 2002

NYC 9/11 Public Portal Document

Table 15. Experiment B: BAL Cell Numbers after Nose-Only Exposure’ became less responsive. However, close Group Day BAL Cell Number (X IQ-^I examination of the data from experiment B Mac Neut Eos Lym showed it was more variable than that from Air 1 14.80 0.012 0.003 0.046 experiment A. Therefore, although the Air Day 6 3.11 0.004 0.002 0.010 and WTC3 Day 1 groups were less responsive to WTC3 1 17.48 0.006 0.000 0.067 Meh aerosol challenge than the other four groups, 3.13 0.003 0.000 0.013 the biological significance of this finding is Air 3 16.56 0.008 0.000 0.125 unclear. 1.13 0.004 0.000 0.041 6. BAL parameters. Numbers of BAL cells i~ ~i Quantified 1,3, and 6 days after nose-only WTC3 3 26.72 0.034 0.016 QQjg exposure to Air or WTC3 (Table 15). Analysis of 3.11 0.017 0.009 (Tl^ showed that mice exposed to WTC3 had Air 6 22.24 0.000 0.000 significantly greater numbers of macrophages (P 1.13 0.000 0.BSE ■--------------- - =0.01) and lymphocytes (P = 0.02) compared WTC3 6 29.86 0.019 0.005 I 0-281 I Air-exposed mice. Macrophage numbers 2.58 0.008 0.004 1_ 21°^ _J were significantly greater on Day 6 vs. Day 1, and ' Values shown are means (in bold) and SEM immediately below means (n=8 per lymphocyte numbers were significantly greater on both Day 3 and Day 6 vs. Day 1. Over all time Day 6 different from Day 1. Dashed-line boxes; Significant difference (P=0.02) . • 4 j oon/ between Air and WTC3, Day 3 and Day 6 both different from Day 1. pomts, WTC3 mice had 38 /o more macrophages, and 75% more lymphocytes (Figure 13). data. These results could be interpreted as saying that However, macrophages comprised 99% of all recovered mice exposed to WTC3 became more responsive to Meh cells in both groups at all time points. Lymphocytes in the days following exposure, while Air-exposed mice constituted about 1% or less of total BAL cells, while both

Mac Neut 35 a 0.6-1

30 □ Air □ Air HWTC3 -T' 25 HWTC3 e 0.4- C 20 Ml

's 15 U u 0.2- 10 5 0 0.0 ___ Day 1 Day. 3 Day 6 Day 1 Day 3 Day 6

Eos Lym 0.6-1 0.6-1

EZZlAir □ Air ■■WTC3 ■■WTC3 C 0.4- ’o 0.4- b Ml Ml

'3 b

J 0.2- 0.2-

0.0-J—------ 0.0 Day 1 Day 3 Day 6 Day 1 Day 3 Day 6 Figure 13. Experiment B; Bronchoalveolar lavage cell numbers recovered from mice 1, 3, or 6 days after 5 hr nose-only inhalation exposure to WTC sample 3 or Air only. Values shown are means and SEM (n=8 per group). Cell types shown are macrophages and monocytes (Mac), eosinophils (Eos), neutrophils (Neut), and lymphocytes (Lym). “ Significant difference (P = 0.01) between Air and WTC3, Day 6 different from Day 1. Significant difference (P = 0.02) between Air and WTC3, Day 3 and Day 6 different from Day 1.

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