NYC-WTC_000195937

NYC 9/11 Public Portal Document

MSDS Number. 2008FR Page 6 of7

exposures to 50,000 ppm (v/v) of vapors produced organ weight increases and a decrease in body weight gain, but no increased mortality or adverse hematological effects. In chronic inhalation studies, "FREON" 22, at a concentration o 50,000 ppm (v/v), produced a small, but statistically significant increase of late-occurring tumors involving salivary glands in male rats, but not female rats or male or female mice. In the same studies, no Increased incidence of tumors was seen in either species at concentrations of 10,000 ppm or 1,000 ppm (v/v).

Long-term administration in corn oil produced no effects on body weight or mortality.

"FREON" 22 was mutagenic in some strains of bacteria in bacterial cell cultures, but not mammalian cell cultures or animals. It did not cause heritable genetic damage in mammals.

A slight, but significant increase in developmental toxicity was observed at high concentrations (50,000 ppm) of "FREON" 22, a concentration which also produced toxic effects in the adult animal. Based on these findings, and other negative developmental studies, "FREON" 22 is not considered a. unique hazard to the conceptus. Studies of the effects of "FREON" 22 on male reproductive performance have been negative. Specific studies to evaluate the effect on female reproductive performance have not been conducted, however, limited information obtained from studies on developmental toxicity do not indicate adverse effects on female reproductive performance at concentrations up to 50,000 ppm.

ECOLOGICAL INFORMATION Ecotoxicological Information

Aquatic Toxicity;

"FREON" 22

48 hour EC50 - Daphnia inagna: 433 mg/L

DISPOSAL CONSIDERATIONS Waste Disposal

Comply with Federal, State, and local regulations. Reclaim by distillation or remove to a permitted waste disposal facility.

TRANSPORTATION INFORMATION Shipping Information

DOT/IMO Proper Shipping Name : CHLORODI FLUOROMETH7U4E Hazard Class ; 2.2

http://www.dupont.eom/msds/40_37_2008fr.html 12/12/2001

CITY_21MC100_003113536

NYC-WTC_000195942