NYC-WTC_000195068

NYC 9/11 Public Portal Document

ASBESTOS MEDITEXT ® - Medical Management Page 5 of 15

have been few attempts to correlate hemolytic activity with ferruginous bodies (Ayer et al, 1972). d. While they are probably formed as a protective mechanism, ferruginous bodies are not biologically inert. Included iron can induce DNA damage and may play a role in formation of hydroxyl radicals and lipid peroxidation (Lund et al, 1994).

. OTHER

1. Asbestos, as a component of industrial dust, may also produce chronic obstructive airways disease, but further study is required to confirm and understand this relationship (Zejda, 1996).

. CARCINOMA

1. RISK FACTOR - Asbestosis patients with progression of small opacities on chest x-ray over several years are at higher risk of developing lung cancer (Oksa et al, 1998). Although smoking history is also a factor in lung cancer, progression of pulmonary fibrosis may be an independent risk factor.

3.10 GENITOURINARY

3.10.1 ACUTE EFFECTS

A. RENAL FAILURE ACUTE 1. CASE REPORT - Acute renal failure has been reported secondary to retroperitoneal fibrosis which developed in a man with diffuse asbestos-related pleural fibrosis (Maguire et al, 1991).

3.13 HEMATOLOGIC

3.13.1 ACUTE EFFECTS

A. LEUKEMIA ACUTE 1. CASE REPORT - Two men who worked in a shipyard for 40 years were diagnosed with acute myelocytic leukemia (Kishimoto et al, 1988). a. The concentrations of asbestos bodies in their lungs were comparable to those in a control group of 10 patients with lung cancer and similar occupational histories. b. Both patients, but none of the controls, had asbestos bodies in the bone marrow.

3.14 DERMATOLOGIC

3.14.1 ACUTE EFFECTS

A. NEOPLASM SKIN 1. ASBESTOS CORNS - Warts or areas of thickened skin surrounding implanted asbestos fibers do NOT lead to skin tumors and disappear on removal of the fibers (ILO, 1983).

3.19 IMMUNOLOGIC

3.19.1 ACUTE EFFECTS

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