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NYC-WTC_000195068
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NYC 9/11 Public Portal Document
ASBESTOS MEDITEXT ® - Medical Management Page 3 of 3
with smoking. D. There is growing interest in the possible role of free radicals in asbestos-mediated carcinogenesis. Peroxides enhance the activity of asbestos in causing DNA damage (Mahmood et al, 1993; Mahmood et al, 1994). Peroxides react with ferrous ion complexed to asbestos particles to generate free radicals and DNA damage (Ohio et al, 1994). E. Mononuclear peripheral leukocytes from patients with lung cancer were more active for generating reactive oxygen species in the presence of asbestos than were cells from patients without cancer. The level of reactive oxygen generation was inversely correlated with one-year survival rates in these patients (Nyberg et al, 1994). F. Asbestos can induce expression of c-fos and c-jun oncogenes in rat pleural mesothelial cells; crocidolite was more active than chrysotile for this effect, as it is for induction of mesothelioma (Heintz et al, 1993).
http://www.tomescps.com/DATA/TM/TM356-9.htm 1/4/2002
CITY_21MC100_011105081
NYC-WTC_000195099
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NYC-WTC_000195099Source: NYC Law Department, mirrored locally
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