VOC sampling locations table for Ground Zero area, Jan 2002

NYC 9/11 Public Portal Document

samples compared with the response induced by the Figure 17. (previous page.) Experiment C: Bronchoalveolar lavage supernatant proteins and enzymes recovered from mice pooled WTCX sample in Experiment A, although differing exposed to saline vehicle, NIST 1649a, or WTC PM samples responsiveness of different shipments of mice could from individual collection sites and tested 1 or 3 days later (n account for this finding, and a direct comparison would be = 8 per group except Saline sub-experiment C2: n = 4). “ necessary to determine if there is a difference. Numbers Significantly greater protein values in NIST group vs. WTC8 of neutrophils declined from Day 1 to Day 3 after group. Other significant differences were found due to Day oropharyngeal aspiration, as determined by both BAL and of sacrifice or interactions between Day and Treatment, but histopathologic examination. Other cell types appeared to there were no other effects due to Treatment alone. be more persistent or increase from Day 1 to Day 3 (especially lymphocytes in sub-experiment Cl), but these were not large changes. Respiratory responsiveness to Meh aerosol was significantly increased in all WTC 6. Summary. Examination of the effects of WTC groups compared with saline controls, although mice PM collected from different locations surrounding the exposed to WTC 13 were less responsive than other WTC WTC site showed that all samples were capable of groups. The degree of Meh hyperresponsiveness in the inducing pulmonary inflammation and WTC groups of Experiment C appeared to be comparable hyperresponsiveness to Meh aerosol, although overt lung to that from the WTCX group in Experiment A. damage as determined by biochemical parameters of lung No particular geographical significance could be injury was minimal. The neutrophilic response was deduced from the patterns of responses induced by the substantially greater for all individual site WTC PM individual WTC PM samples. The one group which had

Table 21. Experiment C - Summary of Treatment-Related Histopathologic Findings in Mice 1 or 3 Days after Intratracheal Instillation of Particulate Matter Samples “ Bronchiole, Bronchiole, Bronchiole, Treatment Sub- Inflammation, Pigment, Pigment, Group Experiment Day Subacute, Focal Macrophage, Focal Free, Focal Incidence Severity Incidence Severity Incidence Severity WTC13 Cl 8/8 2.1 8/8 2.0 4/8 0.6 WTCE C2 8/8 2.0 8/8 1.9 2/8 0.3 NIST Cl 8/8 1.9 7/8 2.0 7/8 0.9 WTCII C2 8/8 1.3 7/8 0.9 0/8 0.0 WTCF Cl 8/8 1.3 6/8 0.8 0/8 0.0 WTC8 Cl 6/8 1.1 6/8 0.8 0/8 0.0 WTCB C2 1 6/8 1.1 6/8 0.8 0/8 0.0 WTCC C2 1 6/8 0.8 4/8 0.5 0/8 0.0 Saline Cl 1 1/8 0.1 0/8 0.0 0/8 0.0 NIST Cl 3 8/8 2.1 8/8 2.0 0/8 0.0 WTCll C2 3 6/8 I.l 2/8 0.3 0/8 0.0 WTCE C2 3 6/8 0.8 6/8 0.8 0/8 0.0 WTC8 Cl 3 4/8 0.8 1/8 0.1 0/8 0.0 WTC13 Cl 3 4/8 0.6 3/8 0.4 0/8 0.0 WTCB C2 3 3/8 0.4 2/8 0.3 0/8 0.0 WTCF Cl 3 3/8 0.4 1/8 0.1 0/8 0.0 WTCC C2 3 2/8 0.3 1/8 0.1 0/8 0.0 Saline Cl 3 0/7 0.0 0/7 0.0 0/7 0.0

“ Saline-instilled control mice in sub-experiment C2 were not examined. Incidence denotes number ofmice in group with finding / total number ofmice examined. Average severity score for the group is shown based on the following scoring system: 0 = not present, 1 = minimal, 2 = slight/raild, 3 = moderate, 4 = moderately severe, 5 = severe/high. Groups are arranged in descending order of severity within each post-exposure day, first by severity of focal subacute bronchiolar inflammation, and then by severity of focal bronchiolar pigmented macrophages.

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NYC-WTC_000149184